IN SILICO EVALUATION ON THE INTERACTION BETWEEN KETONE BODIES AND OBESITY-ASSOCIATED PROTEINS
- Project Research
- 1-5 Chapters
- Qualitative
- Library / Doctrinal
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
Background of study
Obesity, has been a pre-existing problem afore time but has been recognized as a global pandemic since the 21st century (Natalia, et al., 2021). Aronne, 2002 defines obesity as the anomalous, irregular or disproportionate gain of weight as a result of fat buildup in the body which adversely leads to the risk of several health related problems such as hypertension, type 2 diabetes, cardiovascular diseases and certain cancer types amongst others (Aronne, 2002; Natalia, et al., 2021; Williams, et al., 2015).
Obesity calculation is based on body mass index ≥ 30kg/m2 which is the measurement of fat buildup by dividing body mass (kg) by the square of the body height (m2) (Aronne, 2002; Kopelman, 2000). In 2016, WHO (world health organization) acknowledged that nearly 2-billion adults worldwide were measured to be overweight and 650 million of that population were found to be obese. The WHO, also estimated that 50% of the population found in Europe had preeminent body weight which could lead to obesity overtime (WHO, 2016).
Furthermore in 2002, certain rural areas in Nigeria were recorded to have a high rate of obesity at 33.7% (Ogah, 2013). Obesity mechanism, involves a complex process and certain physical and biochemical factors have been found to induce this condition some of which include unhealthy diets and eating habits, high calorie food consumption, genetic, epigenetic, and ecological factors. All these factors combined together with the lack of physical activity to burn excess body weight then lead to energy disproportion and fat deposition (William, et al., 2015; Lin, et al., 2017). Due to obesity prevalence overtime, several solutions and control measures have been brought up to ameliorate as well as control the condition. Some of these measures, include physical activity programmes, behavioral lifestyle programmes, pharmacotherapy, diet management, and in severe obese conditions bariatric surgery is recommended (Gonzalez-Muniesa, et al., 2017).
Caloric inhibition, a diet management scheme and nutritional strategy is the commonly used weight loss mechanism as far as diet management is concerned and this research focuses on the use of ketogenic diet which was used successfully in the therapy of epilepsy, as a control measure for obesity (Anton, et al., 2017; Ulamek-Koziol, et al., 2019).
Ketogenic diet is made up of an augmented fat content, minimal carbohydrate content and sufficient amount of protein content. As a result of the proportionate amount of nutrient in the diet composition, there is reduced metabolism of carbohydrate and protein but increased metabolism of fat (Kayode, et al., 2020).
Consequent fat breakdown and reduced carbohydrate and protein breakdown, then leads to reduced blood glucose levels and the stimulation of ketogenesis in the liver which produces increased levels of ketone bodies and fatty acids (Sanjay, et al., 2018; Kulaka and Polotsky, 2013). The resulting ketone bodies are then transported to the blood brain barrier to make available energy for the brain and increased levels of the ketone bodies lead to increased levels of substrates such as creatine, adenine triphosphate (ATP), and phosphocreatine that are essential in the brain (Kayode, et al., 2021; Sanjay, et al., 2018).
1.2 Statement of the Problem and objective of study
Obesity, is a predominant disease occurring in a yearly estimate of over 2 billion individuals as a result of excessive fat buildup and this has led to numerous health issues and conditions. With the prevalence of obesity in recent times, several control measures were proposed so as to ameliorate the condition. This study aims at exploring the efficiency of ketogenic diet generated ketone bodies in the prevention and amelioration of obesity using in silico simulations.
Related Project Materials
MODELING THE EFFECTS OF CARRIERS ON TRANSMISSION DYNAMICS OF INFECTIOUS DISEASES
BACKGROUND OF STUDY
For certain infectious diseases, there are individuals who are able to tran...
A COMPARATIVE ANALYSIS OF THE CONFLICT SITUATIONS AND CHOICE OF LAWS IN THE NIGERIAN LEGAL SYSTEM AND OTHER LEGAL SYSTEMS
ABSTRACT
The study provided a comparative Analysis Of The Conflict Situations And Choice Of Laws In The Nigerian Legal S...
AN EVALUATION OF ELECTORAL VIOLENCE IN NIGERIA: THE CASE OF ANAMBRA STATE GUBERNATORIAL ELECTIONS
BACKGROUND OF THE STUDY
The unbridled quest for power by man in his ever unstoppable search for relevan...
A PRAGMATIC STUDY OF SOME SELECTED POLITICAL POSTERS
ABSTRACT
This long essay focuses on the pragmatics study of selected political posters impr...
AN EVALUATION OF COMPETITIVE STRATEGY AND ITS IMPACT ON AND ORGANIZATIONAL PERFORMANCE IN THE NIGERIAN BANKING INDUSTRY
BACKGROUND OF THE STUDY
The name Bank is derived from the Italian word banco, which means "desk/be...
APPLICATION OF AUDIO VISUAL AIDS IN TEACHING ACCOUNTING IN SENIOR SECONDARY SCHOOLS
ABSTRACT
This project work was undertaken to survey the use of audio visual aids in the teaching and le...
INTRODUCTION TO ARTIFICIAL INTELLIGEINCE APPLICATION AND BENEFITS TO HUMAN LIFE
ABSTRACT
This study was intended to examine the historical development of artificial intelligence. This study was guided...
NEXUS BETWEEN UNDERWRITING OPERATION AND FINANCIAL PERFORMANCE OF NON-LIFE INSURANCE COMPANIES IN NIGERIA
BACKGROUND TO THE STUDY
Insurance is a provision of a system of compensation for loss, damage, sickness, death and other...
EFFECTIVENESS OF PUBLIC RELATIONS ACTIVITIES ON TERTIARY INSTITUTIONS
ABSTRACT
The purpose of this study was to appraise public relations activities in tertiary institutions...
CHALLENGES OF PROLIFERATION OF SMALL ARMS AND LIGHT WEAPONS TO PEACE-BUILDING IN LIBERIA AND SIERRA LEONE
ABSTRACT
This study focuses on the challenges of proliferation of small arms and light weapons (SALW) to peace-building in Liberia and Si...
